Porlier G A, Nadeau R A, De Champlain J, Bichet D G
Can J Physiol Pharmacol. 1977 Jun;55(3):724-33. doi: 10.1139/y77-097.
Circulating plasma catecholamines, plasma renin activity, and other variables were measured in unanesthetized dogs before and after chemical sympathectomy with 6-hydroxydopamine (6-OHDA, 50 mg/kg). Chemical sympathectomy resulted in an immediate fall in mean arterial blood pressure and a delayed reduction in heart rate. Significant increases in plasma glucose and lactate concentrations, circulating plasma catecholamines, and plasma renin activity were found 24 h after 6-OHDA treatment. Circulating catecholamine levels decreased rapidly as time elapsed after sympathectomy and were half the initial values after 2 weeks. Plasma renin activity remained elevated during the 1st week after 6-OHDA treatment and returned to control levels during the 2nd week. Significant correlations were found between circulating catecholamines and heart rate mean arterial pressure, and plasma glucose and lactate concentrations. A significant correlation was also found between plasma renin activity and the mean arterial blood pressure. These results confirm that the adrenal medulla increases its catecholamine secretion rate into the circulation to compensate for the loss of adrenergic innervation after 6-OHDA treatment. They also indicate that the renin-angiotensin system represents another important compensatory mechanism for circulatory homeostasis in sympathectomized animals.
在用6-羟基多巴胺（6-OHDA，50mg/kg）进行化学交感神经切除术前和术后，对未麻醉犬的循环血浆儿茶酚胺、血浆肾素活性及其他变量进行了测量。化学交感神经切除导致平均动脉血压立即下降，心率延迟降低。在6-OHDA治疗24小时后，发现血浆葡萄糖和乳酸浓度、循环血浆儿茶酚胺及血浆肾素活性显著升高。交感神经切除术后，随着时间推移，循环儿茶酚胺水平迅速下降，2周后降至初始值的一半。6-OHDA治疗后第1周血浆肾素活性持续升高，第2周恢复至对照水平。循环儿茶酚胺与心率、平均动脉血压以及血浆葡萄糖和乳酸浓度之间存在显著相关性。血浆肾素活性与平均动脉血压之间也存在显著相关性。这些结果证实，肾上腺髓质增加其儿茶酚胺分泌进入循环，以补偿6-OHDA治疗后肾上腺素能神经支配的丧失。它们还表明，肾素-血管紧张素系统是交感神经切除动物循环稳态的另一个重要代偿机制。
