Silva F, Garcia L, Flores C, Storer D, Aguiló F
Department of Radiological Sciences, School of Medicine, University of Puerto Rico, Rio Piedros, Puerto Rico 00936-5067.
Clin Nucl Med. 1996 Mar;21(3):218-20. doi: 10.1097/00003072-199603000-00007.
A case in which a prolonged hypothyroid state resulted in development of a pericardial effusion is presented. The compensatory mechanism for protein homeostasis is lost in severe hypothyroidism. Iodine is transported to the pericardial space, which is filled with a high-protein content fluid and remains trapped. The mechanism for the accumulation of the fluid in the pericardial space is discussed. To prevent this unusual but dangerous complication, the authors recommend close monitoring of the patient's clinical status and serum thyroid stimulating hormone. The use of a short acting thyroxine substitute for at least 2 weeks can decrease occurrence of this complication and will shorten the time the patient needs to be hypothyroid.
本文介绍了一例因长期甲状腺功能减退导致心包积液的病例。在严重甲状腺功能减退时，蛋白质稳态的代偿机制丧失。碘被转运至心包腔，心包腔内充满高蛋白含量的液体并被困在其中。本文讨论了心包腔内液体积聚的机制。为预防这种罕见但危险的并发症，作者建议密切监测患者的临床状态和血清促甲状腺激素。使用短效甲状腺素替代物至少2周可减少该并发症的发生，并缩短患者甲状腺功能减退的时间。
