Carmichael S T, Price J L
Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
J Comp Neurol. 1995 Dec 25;363(4):642-664. doi: 10.1002/cne.903630409.
Sensory and premotor inputs to the orbital and medial prefrontal cortex (OMPFC) were studied with retrograde axonal tracers. Restricted areas of the lateral and posterior orbital cortex had specific connections with visual-, somatosensory-, olfactory-, gustatory-, and visceral-related structures. More medial areas received few direct sensory inputs. Within the lateral and posterior orbital cortex, area 12l received a substantial projection from visual areas in the inferior temporal cortex (TE). Area 12m received somatosensory input from face, digit, or forelimb regions in the opercular part of area 1-2, in area 7b, in the second somatosensory area (SII), and in the anterior infraparietal area (AIP). Areas 13m and 13l also received a projection from the opercular part of areas 1-2 and 3b. The posteromedial and lateral agranular insular areas (Iapm and Ial, respectively) received fibers from the ventral part of the parvicellular division of the ventroposterior medial nucleus of the thalamus (VPMpc) that may represent a visceral afferent system. The dorsal part of VPMpc projected to the adjacent gustatory cortex. These restricted inputs from several sensory modalities and the convergent corticocortical connections to orbital areas 13l and 13m suggest a network related to feeding. The OMPFC was also connected to premotor cortex in ventral area 6 (areas 6va and 6vb), in cingulate area 24c, and probably in the supplementary eye field. Area 6va projected to area 12m, whereas a region of area 6vb projected to area 13l. The region of the supplementary eye field projected to areas 12l, 12o, and 12r. Area Ial received fibers from area 24c. Lighter and more diffuse projections also reached wider areas of the OMPFC. For example, injections in several orbital areas labeled a few cells scattered through the anterior part of area TE and the superior temporal gyrus. There was also a projection to the intermediate agranular insular area (Iai) and to areas 13a and 12o from the apparently multimodal areas in the superior temporal sulcus and gyrus.
利用逆行轴突示踪剂研究了向眶额和内侧前额叶皮层（OMPFC）的感觉和运动前输入。外侧和后部眶皮层的特定区域与视觉、体感、嗅觉、味觉和内脏相关结构有特定连接。更内侧的区域几乎没有直接的感觉输入。在外侧和后部眶皮层内，12l区接受来自颞下皮层（TE）视觉区域的大量投射。12m区接受来自1-2区 opercular 部分、7b区、第二体感区（SII）和前顶下区（AIP）的面部、手指或前肢区域的体感输入。13m区和13l区也接受来自1-2区和3b区 opercular 部分的投射。后内侧和外侧无颗粒岛叶区（分别为Iapm和Ial）接受来自丘脑腹后内侧核小细胞部腹侧部分（VPMpc）的纤维，这可能代表一个内脏传入系统。VPMpc的背侧部分投射到相邻的味觉皮层。来自几种感觉模态的这些受限输入以及与眶区13l和13m的汇聚性皮质皮质连接提示了一个与进食相关的网络。OMPFC还与腹侧6区（6va和6vb区）、扣带24c区以及可能的辅助眼区的运动前皮层相连。6va区投射到12m区，而6vb区的一个区域投射到13l区。辅助眼区的区域投射到12l区、12o区和12r区。Ial区接受来自24c区的纤维。更轻且更弥散的投射也到达了OMPFC更广泛的区域。例如，在几个眶区注射标记了散布在TE区前部和颞上回的一些细胞。从颞上沟和颞上回明显的多模态区域也有投射到中间无颗粒岛叶区（Iai）以及13a区和12o区。
