新生大鼠和成年大鼠L5腹根中大型运动轴突的髓鞘长度。

Sheath lengths of large motor axons in the ventral root L5 of neonatal and adult rats.

作者信息

Hildebrand C, Loeliger S, Bjartmar C, Karlsson M

机构信息

Department of Cell Biology, University of Linköping, Sweden.

出版信息

Neurosci Lett. 1996 Jan 5;202(3):173-76. doi: 10.1016/0304-3940(95)12242-7.

DOI:10.1016/0304-3940(95)12242-7

PMID:8848259

Abstract

This study examines the developmental sheath elongation in the rat ventral root L5. Electron microscopic analysis of serial transverse sections through roots from newborn rats shows an average internuclear distance (IND) of 66 microns (calculated fresh length 73 microns). Light microscopic analysis of teased adult roots shows that the largest fibers have an average internodal length of some 1250 microns at 5 months. Hence, large fibers exhibit a developmental sheath elongation of 17 times. The ventral root L5 elongates 11 times only. This mismatch necessitates a myelin sheath remodelling.

摘要

本研究考察了大鼠腰5腹根中发育性髓鞘伸长情况。对新生大鼠神经根的系列横切片进行电子显微镜分析显示，平均核间距离（IND）为66微米（计算得出的新鲜长度为73微米）。对分离的成年神经根进行光学显微镜分析表明，5个月大时最大的纤维平均节间长度约为1250微米。因此，大纤维的发育性髓鞘伸长为17倍。而腰5腹根仅伸长11倍。这种不匹配使得髓鞘重塑成为必要。