Nunomura A, Chiba S, Eto M, Saito M, Makino I, Miyagishi T
Department of Psychiatry and Neurology, Asahikawa Medical College, Japan.
Neurosci Lett. 1996 Mar 8;206(1):17-20. doi: 10.1016/0304-3940(96)12415-0.
Apolipoprotein E (ApoE) phenotypes and corresponding allele frequencies were examined in 72 patients (50-90 years of age) with sporadic Alzheimer's disease (AD) and 83 elderly controls (61-96 years of age) in Hokkaido, the northern part of Japan. The frequency of the ApoE-epsilon 4 allele was significantly higher in the patients with either early-onset (age < 65 years) AD (0.40) or late-onset AD (0.26) than in controls (0.07), while the patients developing AD before 50 years of age had no epsilon 4 allele. The mean age at onset of AD was significantly lower in the ApoE-epsilon 4 homozygotes compared to that in the patients with either one or no epsilon 4 allele (60.2, 71.3 and 70.3 years, respectively). Our results indicate that the ApoE-epsilon 4 allele is associated with susceptibility to Japanese sporadic AD developing after 50 years of age and homozygosity for the epsilon 4 allele shifts the onset to earlier age.
在日本北部北海道地区，对72例散发性阿尔茨海默病（AD）患者（年龄50 - 90岁）和83名老年对照者（年龄61 - 96岁）进行了载脂蛋白E（ApoE）表型及相应等位基因频率检测。早发型（年龄<65岁）AD患者（0.40）或晚发型AD患者（0.26）中ApoE-ε4等位基因频率显著高于对照者（0.07），而50岁前发病的AD患者无ε4等位基因。与携带一个或不携带ε4等位基因的患者相比，ApoE-ε4纯合子AD患者的平均发病年龄显著更低（分别为60.2岁、71.3岁和70.3岁）。我们的结果表明，ApoE-ε4等位基因与50岁后发生的日本散发性AD易感性相关，且ε4等位基因纯合性会使发病年龄提前。
