Gong W, Neill D B, Justice J B
Department of Psychology, Emory University, Atlanta, GA 30322, USA.
Pharmacol Biochem Behav. 1996 Jan;53(1):185-90.
Previous studies have demonstrated that rats showing a strong locomotor response to a novel environment have a greater locomotor response to psychostimulant drugs and more rapidly acquire intravenous self-administration of amphetamine. In this report, we examined whether these high-responder (HR) rats would develop place-preference conditioning with cocaine more readily than low-responder (LR) rats. Neither group of rats developed conditioned place preference for cocaine, 2.5 mg/kg, intraperitoneally (IP). Both groups of rats developed conditioned place preference for cocaine, 5.0 and 15 mg/kg, IP. However, we could not find any evidence of enhanced conditioning in the HR rats. HR rats did show a greater locomotor response to cocaine, 15 mg/kg, IP, and the locomotor response of HR and LR rats to cocaine correlated with their response to a novel environment. We conclude that using the place-preference procedure, HR and LR rats do not differ in the rewarding effect of cocaine.
先前的研究表明，对新环境表现出强烈运动反应的大鼠对精神刺激药物有更大的运动反应，并且能更快地学会静脉注射苯丙胺进行自我给药。在本报告中，我们研究了这些高反应性（HR）大鼠是否比低反应性（LR）大鼠更容易对可卡因产生位置偏爱条件反射。两组大鼠均未对腹腔注射（IP）2.5mg/kg可卡因产生条件性位置偏爱。两组大鼠均对腹腔注射5.0和15mg/kg可卡因产生了条件性位置偏爱。然而，我们没有发现HR大鼠有增强条件反射的任何证据。HR大鼠对腹腔注射15mg/kg可卡因确实表现出更大的运动反应，并且HR和LR大鼠对可卡因的运动反应与其对新环境的反应相关。我们得出结论，使用位置偏爱程序时，HR和LR大鼠在可卡因的奖赏效应方面没有差异。
