Melchior C L, Ritzmann R F
Department of Psychiatry, Olive View/UCLA Medical Center, Sylmar, CA 91342, USA.
Pharmacol Biochem Behav. 1996 Jan;53(1):51-6. doi: 10.1016/0091-3057(95)00197-2.
Using a win-shift foraging paradigm to assess working memory in C57BL/6 mice, the memory-enhancing effect of low doses of the neurosteroids 5-pregnen-3 beta-ol-20-one [pregnenolone (PE)], 5-pregnen-3 beta-ol-20-one sulfate [pregnenolone sulfate (PS)], 5-androsten-3 beta-ol-17-one [dehydroepiandrosterone (DHEA)], and 5-androsten-3 beta-ol-17-one sulfate [dehydroepiandrosterone sulfate (DHEAS)] were demonstrated. The neurosteroids 5 beta-pregnan-3 alpha-ol-20-one [pregnanolone (PA)] and 5 beta-pregnan-3 beta-ol-20-one [epipregnanolone (EPI)] disrupted memory in this paradigm. PE, PS, DHEA, DHEAS, and PA were also capable of blocking the memory-impairing effect of 0.5 g/kg ethanol. EPI prevented PA from blocking the effect of ethanol. The influence of these compounds on memory and their interactions on this behavior are consistent with their actions on the GABAA system.
使用win-shift觅食范式评估C57BL/6小鼠的工作记忆，结果表明低剂量神经甾体5-孕烯-3β-醇-20-酮[孕烯醇酮（PE）]、5-孕烯-3β-醇-20-酮硫酸盐[硫酸孕烯醇酮（PS）]、5-雄烯-3β-醇-17-酮[脱氢表雄酮（DHEA）]和5-雄烯-3β-醇-17-酮硫酸盐[硫酸脱氢表雄酮（DHEAS）]具有记忆增强作用。神经甾体5β-孕烷-3α-醇-20-酮[孕烷醇酮（PA）]和5β-孕烷-3β-醇-20-酮[表孕烷醇酮（EPI）]在该范式中破坏记忆。PE、PS、DHEA、DHEAS和PA也能够阻断0.5 g/kg乙醇的记忆损害作用。EPI阻止PA阻断乙醇的作用。这些化合物对记忆的影响及其在该行为上的相互作用与其对GABAA系统的作用一致。
