Motta A, Faletti A, Gimeno M A
Centro de Estudios Farmacológicos y Botánicos, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina.
Prostaglandins. 1995 Oct;50(4):213-23. doi: 10.1016/0090-6980(95)00123-9.
We measured the synthesis and secretion of uterine prostaglandins E and F2 alpha (PGE and PGF2 alpha) by the uterus in vitro from pseudopregnant (psp) rats on days 5 and 10 of psp, when level of serum progesterone was high and low, respectively. We found a direct correlation between concentration of progesterone in serum and uterine content of PGE and an inverse correlation with uterine PGF2 alpha. On day 5, when progesterone was high in serum, PGE increased in tissue more than in the incubation medium, suggesting a poor liberation of this PG or utilization of PGE by the tissue. On this day, no difference was seen between content of uterine PGF2 alpha and PGF2 alpha in the incubation medium. Nevertheless, on day 10, when progesterone was lower, concentrations of both PGE and PGF2 alpha were greater (P < 0.001) in the medium than in the uterine tissue. However, PGF2 alpha in the medium was higher than PGE (P < 0.05). The results clearly demonstrate that the synthesis and release of PGE and PGF2 alpha were modified by the concentration of progesterone in the serum.
我们在假孕（psp）大鼠假孕第5天和第10天，分别在血清孕酮水平高和低时，体外测量了子宫中前列腺素E和F2α（PGE和PGF2α）的合成与分泌。我们发现血清孕酮浓度与子宫PGE含量之间存在直接相关性，与子宫PGF2α含量呈负相关。在第5天，血清孕酮水平高时，组织中PGE的增加幅度大于孵育培养基中的增加幅度，这表明该前列腺素释放较差或组织对PGE的利用率较高。在这一天，子宫PGF2α含量与孵育培养基中PGF2α含量之间没有差异。然而，在第10天，当孕酮水平较低时，培养基中PGE和PGF2α的浓度均高于子宫组织（P < 0.001）。然而，培养基中的PGF2α高于PGE（P < 0.05）。结果清楚地表明，PGE和PGF2α的合成与释放受到血清孕酮浓度的影响。
