Largiadèr F
Department Chirurgie, Universitätsspital Zürich.
Schweiz Med Wochenschr. 1996 Aug 24;126(34):1433-6.
Simultaneous transplantation of the pancreas and the kidney performed in our institution up to 1979 in patients with diabetic nephropathy and terminal renal failure did not result in long-term success. The same procedure was applied to 13 patients with the same indication from 1980 to 1982. The technique of pancreatic transplantation was a segmental transplantation with instantaneous or delayed duct occlusion. Immunosuppressive therapy included azathioprine and prednisone, and in some patients antilymphocyte globulin, but no cyclosporin. 5 of these patients are still living; 4 of them lost their pancreas transplant function after 2 months, 5 months, 9 months and 5 years respectively. One female patient is living 15 years after transplantation, with good function of both the pancreas and the kidney. This is the longest functional survival after pancreas and kidney transplantation in the world literature.
1979年以前，在我们机构对患有糖尿病肾病和终末期肾衰竭的患者进行胰腺和肾脏同时移植，并未取得长期成功。1980年至1982年，对13例有相同适应证的患者采用了同样的手术。胰腺移植技术为节段性移植，采用即时或延迟的导管闭塞。免疫抑制治疗包括硫唑嘌呤和泼尼松，部分患者使用抗淋巴细胞球蛋白，但未使用环孢素。其中5例患者仍存活；4例分别在术后2个月、5个月、9个月和5年后失去胰腺移植功能。1例女性患者移植后存活15年，胰腺和肾脏功能良好。这是世界文献中胰腺和肾脏移植后功能存活时间最长的病例。
