Bosticardo G M, Avalle U, Serra A, Giacchino F, Molino A, Alloatti S
Servizio di Nefrologia e Dialisi, Ospedale, Ivrea, Torino.
Minerva Urol Nefrol. 1996 Mar;48(1):59-66.
Classical urea kinetic model (UKM) has been followed by several proposals to determine dialysis adequacy either by direct quantification (DDQ), either by simplified two-points formulas (pre- and post-dialysis BUN), or by mUKM, a modified three-point algorithm (pre-post and pre-next dialysis), where urea distribution volume is input to obtain clearance and urea generation rate. Our new formulas (mUKM2) are derived from urea mass balance, and avoid iterative calculation: their results are similar to those obtained by UKM and mUKM when the standard post-dialysis BUN value is employed. On the contrary, when the equilibrated net-rebound value (Cpwnr) is employed their results are very close to the reference DDQ model: however the new approach is simpler and more practical, to measure dialysis dose taking account of the urea rebound phenomenon.
经典尿素动力学模型（UKM）之后出现了几种确定透析充分性的方法，要么通过直接定量（DDQ），要么通过简化的两点公式（透析前和透析后尿素氮），或者通过改良的三点算法mUKM（透析前后和下次透析前），其中输入尿素分布容积以获得清除率和尿素生成率。我们的新公式（mUKM2）源自尿素质量平衡，避免了迭代计算：当采用标准透析后尿素氮值时，其结果与UKM和mUKM所得结果相似。相反，当采用平衡净反弹值（Cpwnr）时，其结果与参考DDQ模型非常接近：然而，新方法更简单、更实用，在考虑尿素反弹现象的情况下测量透析剂量。
