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[缺血性心脏病猝死与机械性创伤死亡中的肾上腺皮质脂质(应激的法医学诊断)]

[Adrenal cortical lipids in sudden death from ischemic heart disease and death from mechanical trauma (the forensic medical diagnosis of stress)].

作者信息

Alisievich V I

出版信息

Sud Med Ekspert. 1995 Oct-Dec;38(4):3-8.

PMID:8848801
Abstract

The basic regularities in the time course of adrenocortical lipids in acute cardiovascular stress and in injuries of different duration are shown. The author hypothesizes that the reticular zone of the cortical substance of the gland is not a zone of cell aging and death but, quite the contrary, a functionally active zone able, together with the adjacent sites of the bundle zone, to meet the requirements of the organism in glucocorticoids during common vital activity but not during stress. The bundle zone of the cortex overloaded with lipids represents a "cholesterol depot" which is mobilized for the synthesis of steroids in emergency. Study of adrenocortical lipids helps detect the reaction to stress and, hence, helps to decide whether the processes were life-time and when they coursed and permits estimation of the speed of dying and detection of the causes and mechanisms of death.

摘要

本文展示了急性心血管应激及不同持续时间损伤过程中肾上腺皮质脂质的时程基本规律。作者推测,肾上腺皮质网状带并非细胞衰老与死亡区域,恰恰相反,它是一个功能活跃区域,在正常生命活动期间,能与相邻的束状带部位共同满足机体对糖皮质激素的需求,但在应激期间则不然。脂质过载的皮质束状带是一个“胆固醇储备库”,在紧急情况下会被动员用于类固醇合成。对肾上腺皮质脂质的研究有助于检测应激反应,从而有助于判断这些过程是否贯穿一生、何时发生,并可估计死亡速度以及查明死亡原因和机制。

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