López Pérez J, Melero Moreno C, Vivanco Martínez J L, Torres Valdivieso M J, Cela de Julián E
Sección de Hemato-Oncología Pediátrica, Hospital 12 de Octubre, Centro Materno-infantil, Madrid.
An Esp Pediatr. 1996 Jun;44(6):557-60.
To evaluate the SIOP protocols in the treatment of mesenchymal tumors.
We present the results obtained in 28 children diagnosed at a single pediatric hematology-oncology unit of having malignant mesenchymal tumors. These diagnoses were made between April 1981 and June 1994 and the children were treated following the consecutive SIOP protocols which have the objective of curing the disease with minimal sequelae. The first four patients with rhabdomyosarcoma were treated with MMT-SIOP 75, the next 9 children, also diagnosed with rhabdomyosarcoma, were treated with MMT-SIOP 84. During the same period of time, there was a case of synovial sarcoma treated only with surgical excision. The last 14 patients were included in the current protocol, initiated in 1989. Eleven of these patients had rhabdomyosarcoma and 3 synovial sarcoma.
Overall survival and event-free survival at 5 years were 58% and 36%, respectively. Toxicity never was an important factor, although it was increasingly frequent and severe as protocols evolved.
We conclude that our results are similar to those obtained in patients treated with SIOP protocols.
评估国际小儿肿瘤学会（SIOP）方案在间充质肿瘤治疗中的效果。
我们展示了在一家儿科血液肿瘤单位确诊为恶性间充质肿瘤的28名儿童所取得的结果。这些诊断于1981年4月至1994年6月期间作出，患儿按照连续的SIOP方案进行治疗，该方案旨在以最小的后遗症治愈疾病。前4例横纹肌肉瘤患者采用MMT - SIOP 75方案治疗，接下来9例同样诊断为横纹肌肉瘤的患儿采用MMT - SIOP 84方案治疗。在同一时期，有1例滑膜肉瘤患者仅接受了手术切除治疗。最后14例患者纳入了1989年开始的现行方案。其中11例患者患有横纹肌肉瘤，3例患有滑膜肉瘤。
5年总生存率和无事件生存率分别为58%和36%。毒性从未成为一个重要因素，尽管随着方案的进展，其出现频率和严重程度越来越高。
我们得出结论，我们的结果与采用SIOP方案治疗的患者所取得的结果相似。
