接受口服补骨脂素紫外线A光化学疗法（PUVA）治疗的泰国患者的皮肤癌和PUVA所致雀斑样痣

Cutaneous carcinoma and PUVA lentigines in Thai patients treated with oral PUVA.

作者信息

Gritiyarangsan P, Sindhavananda J, Rungrairatanaroj P, Kullavanijaya P

机构信息

Institute of Dermatology, Bangkok, Thailand.

出版信息

Photodermatol Photoimmunol Photomed. 1995 Aug;11(4):174-7. doi: 10.1111/j.1600-0781.1995.tb00162.x.

DOI:10.1111/j.1600-0781.1995.tb00162.x

PMID:8850252

Abstract

A total of 113 Thai patients who were treated with oral PUVA from 1979 to 1992 were examined for long-term cutaneous side effects of PUVA. Two psoriatic patients developed PUVA keratosis on non-sun-exposed areas. Both were skin type IV and had had phototherapy with UVB and sunlight previously. The total doses of UVA were 909 J/cm2 and 242 J/cm2 respectively. One psoriatic patient developed Bowen's disease. He had had a cumulative dose of UVA 2207 J/cm2. He also had a past history of arsenic intake and phototherapy with UVB and sunlight. PUVA lentigines were seen in 58 patients (51.4%). It was associated with older age at starting PUVA, higher cumulative UVA dose and greater number of PUVA treatment. This study suggests that previous exposure to other risk factors is important for inducing skin cancer in populations with skin phototype III, IV and V treated with oral PUVA.

摘要

对1979年至1992年期间接受口服补骨脂素紫外线A（PUVA）治疗的113名泰国患者进行了检查，以评估PUVA的长期皮肤副作用。两名银屑病患者在非阳光暴露部位出现了PUVA角化病。两人均为IV型皮肤，之前曾接受过紫外线B（UVB）和阳光光疗。UVA的总剂量分别为909 J/cm²和242 J/cm²。一名银屑病患者发生了鲍恩病。他的UVA累积剂量为2207 J/cm²。他既往有砷摄入史，也曾接受过UVB和阳光光疗。58名患者（51.4%）出现了PUVA雀斑样痣。其与开始PUVA治疗时年龄较大、UVA累积剂量较高以及PUVA治疗次数较多有关。本研究表明，既往暴露于其他危险因素对于在用口服PUVA治疗的皮肤光类型III、IV和V人群中诱发皮肤癌很重要。