Jund R, Feldmann H J, Molls M
Klinik und Poliklinik für Hals-, Nasen- und Ohrenkranke der LMU München.
Laryngorhinootologie. 1996 Jan;75(1):43-7. doi: 10.1055/s-2007-997530.
Experimental data have shown that hypoxic areas in tumors can increase their malignant potential and reduce their sensitivity to chemotherapy and radiation treatment. Until now, the only incomplete data on the oxygenation of human tumors during therapy have been available.
The distribution of partial pressure of oxygen in malignant head and neck processes was measured in four patients with lymph-node metastases by means of invasive computerized histography (system manufactured by Eppendorf). All patients received primary radiation treatment and chemotherapy with a two-week respite after 30 Gy and the first cycle of chemotherapy. The total dose consisted of 70 Gy in the tumor and two cycles of chemotherapy. Oxygen measurements were taken before the onset of treatment, before and after the respite, and after completion of treatment.
In three of the four patients, we measured prominent hypoxic areas in the cancers with PO2 values less than 5 mmHg. The average value was between 12 and 46 mmHg. We were impressed by the observation that oxygenation appeared to improve in every cancer during the respite. Only the patient who showed good initial oxygenation without any measurable hypoxic fraction suffered a complete recurrence six weeks after the completion of therapy.
Prominent areas of hypoxic tissue are present in human head and neck cancers. Radiation treatment and chemotherapy can alter the oxygenation. Further studies are required to investigate the significance of the oxygenation of human head and neck cancers and the changes occurring in it during different types of therapy in order to assess its clinical impact.
实验数据表明，肿瘤中的缺氧区域可增加其恶性潜能，并降低其对化疗和放疗的敏感性。到目前为止，关于人类肿瘤在治疗期间氧合作用的唯一不完整数据已经存在。
通过侵入性计算机组织学（由Eppendorf制造的系统）测量了4例有淋巴结转移的恶性头颈部病变患者肿瘤内的氧分压分布。所有患者均接受了初次放疗和化疗，在30 Gy照射及第一个化疗周期后有两周的间歇期。总剂量包括肿瘤部位70 Gy的照射及两个周期的化疗。在治疗开始前、间歇期前后以及治疗结束后进行氧测量。
在4例患者中的3例中，我们在癌症中测量到明显的缺氧区域，其氧分压值低于5 mmHg。平均值在12至46 mmHg之间。我们对在间歇期每个癌症的氧合似乎都有所改善这一观察结果印象深刻。只有最初氧合良好且无任何可测量缺氧部分的患者在治疗完成六周后出现了完全复发。
人类头颈部癌症中存在明显的缺氧组织区域。放疗和化疗可改变氧合作用。需要进一步研究来调查人类头颈部癌症氧合作用的意义以及在不同类型治疗期间其发生的变化，以便评估其临床影响。
