[D1 receptor mediates dopamine-induced enhancement of electroretinographic oscillatory potentials].
作者信息
Tagawa S, Shirao Y, Tamura T, Kobayashi A, Katoh K
机构信息
Department of Ophthalmology, Kanazawa University School of Medicine.
出版信息
Nippon Ganka Gakkai Zasshi. 1996 Feb;100(2):139-44.
PMID:8851153
Abstract
The inhibitory action of SCH 23390 (SCH, D1-antagonist) or sulpiride (SUL, D2-antagonist) on the dopamine-induced enhancement of the electroretinographic oscillatory potentials was examined in anesthetized albino rabbits. Enhancement of the oscillatory potentials by intravitreal dopamine (50 microM intravitreal concentration) injection was blocked by a simultaneous intravitreal injection of SCH (20 microM) but not by SUL (50 microM, 100 microM). These results suggest that D1-receptor is mainly responsible for the dopamine-induced enhancement of the oscillatory potentials.
摘要
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