从小鼠L1210细胞的细胞核中合成的DNA的性质。
The nature of DNA synthesized in nuclei from mouse L1210 cells.
作者信息
Müllbacher A, Ralph R K
出版信息
Eur J Biochem. 1977 May 16;75(2):347-55. doi: 10.1111/j.1432-1033.1977.tb11535.x.
Abstract
A DNA-synthesizing system in vitro from mouse L1210 cell nuclei is described. A high proportion of the DNA synthesized by the L1210 nuclei in vitro appeared to be covalently linked complementary DNA. DNA synthesis by L1210 nuclei was not inhibited by the anti-leukaemia compound 4'-9-acridinylamino)-methansulphon-m-anisidine, although this drug binds to isolated DNA and is active against L1210 leukaemia.
摘要
本文描述了一种从小鼠L1210细胞核体外合成DNA的系统。体外由L1210细胞核合成的DNA中，很大一部分似乎是共价连接的互补DNA。L1210细胞核的DNA合成不受抗白血病化合物4'-（9-吖啶基氨基）-甲磺基间茴香胺的抑制，尽管这种药物能与分离的DNA结合且对L1210白血病有活性。
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