放线菌酮未能改变急性二异丙基氟磷酸酯（DFP）处理后体温恢复的速率。
Failure of cycloheximide to alter rate of recovery of temperature following acute DFP treatment.
作者信息
Overstreet D H, Schiller G D, Day T A
出版信息
Eur J Pharmacol. 1977 Jul 15;44(2):187-90. doi: 10.1016/0014-2999(77)90105-4.
PMID:885167
Abstract
Cycloheximide, 400 microgram intraventricularly 4 h after a 1 mg/kg i.m. injection of the irreversible anticholinesterase DFP, failed to alter the rate of recovery of temperature to normal. Tolerance to the hypothermic effects of DFP developed at the same rate in cycloheximide-treated rats. These findings suggest that neither recovery from the acute effects of DFP nor tolerance to its chronic effects depends on protein synthesis.
摘要
在腹腔注射1mg/kg不可逆抗胆碱酯酶二异丙基氟磷酸酯（DFP）4小时后，脑室内注射400微克放线菌酮，未能改变体温恢复正常的速率。在经放线菌酮处理的大鼠中，对DFP低温效应的耐受性以相同速率发展。这些发现表明，DFP急性效应的恢复及其慢性效应的耐受性均不依赖于蛋白质合成。
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