Yamada K, Katoh K, Okuyama M
Department of Internal Medicine, Inazawa City Hospital.
Rinsho Ketsueki. 1996 Feb;37(2):161-4.
An 84-year-old female was admitted to our hospital because of fever. Physical examination and computed tomography revealed hepatosplenomegaly without lymphadenopathy. Anemia and thrombocytopenia were noted and the serum levels of LDH, IL-6 and sIL-2R were elevated. Bone marrow aspiration showed infiltration of lymphoma cells and proliferation of histiocytes with hemophagocytosis. Southern blot analyses revealed rearrangements of both IgJH and IgJK genes. She received corticosteroids with improvement of her general state but she died on the 110th hospital day. Necropsy of the spleen showed diffusely proliferating large lymphoma cells, immunoreactive for B cell marker L-26, and scattered histiocytes with hemophagocytosis.
一名84岁女性因发热入住我院。体格检查和计算机断层扫描显示肝脾肿大，无淋巴结病。存在贫血和血小板减少，乳酸脱氢酶、白细胞介素-6和可溶性白细胞介素-2受体的血清水平升高。骨髓穿刺显示淋巴瘤细胞浸润以及伴有噬血细胞现象的组织细胞增殖。Southern印迹分析显示IgJH和IgJK基因均发生重排。她接受了皮质类固醇治疗，全身状况有所改善，但在住院第110天死亡。脾脏尸检显示弥漫性增殖的大淋巴瘤细胞，对B细胞标志物L-26呈免疫反应性，并有散在的伴有噬血细胞现象的组织细胞。
