Podolski J L
Gastroenterol Nurs. 1996 Jul-Aug;19(4):128-36. doi: 10.1097/00001610-199607000-00003.
The identification of the gastric bacterium Helicobacter pylori was a significant advancement in the treatment of peptic ulcer disease. H. pylori infects the gastric mucosa and its eradication is associated with the prevention of ulcer recurrence. The significance of this finding is that bacterial infections can be treated and cured, offering hope to individuals with peptic ulcers. Characteristics of H. pylori and its putative role in ulcer formation are discussed. The recent challenge has been to identify a drug regimen that will effectively eradicate this organism inexpensively and conveniently, while not causing significant side effects. Current diagnostic methods and antimicrobial therapies for H. pylori are also presented. A look to future directions in therapies includes a hoped-for vaccine to prevent gastric infections with H. pylori.
胃细菌幽门螺杆菌的鉴定是消化性溃疡疾病治疗方面的一项重大进展。幽门螺杆菌感染胃黏膜，根除该菌与预防溃疡复发相关。这一发现的意义在于细菌感染可以得到治疗和治愈，为患有消化性溃疡的个体带来了希望。文中讨论了幽门螺杆菌的特征及其在溃疡形成中可能扮演的角色。最近的挑战是确定一种药物疗法，能有效、廉价且方便地根除这种微生物，同时不会引起严重的副作用。文中还介绍了目前针对幽门螺杆菌的诊断方法和抗菌疗法。对未来治疗方向的展望包括有望研发出预防幽门螺杆菌胃部感染的疫苗。
