肾病综合征中的尿路感染

Urinary tract infection in nephrotic syndrome.

作者信息

Gulati S, Kher V, Arora P, Gupta S, Kale S

机构信息

Department of Nephrology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.

出版信息

Pediatr Infect Dis J. 1996 Mar;15(3):237-40. doi: 10.1097/00006454-199603000-00012.

DOI:10.1097/00006454-199603000-00012

PMID:8852912

Abstract

BACKGROUND

The aim was to study the frequency, etiology and predisposing factors of urinary tract infection (UTI) in children with nephrotic syndrome.

METHODS

A retrospective analysis of all children with nephrotic syndrome was made to determine the occurrence of infectious complications.

RESULTS

UTI was found to be the most common infection (40.26%); 49 episodes of culture-positive UTI were observed in 37 children. All 49 episodes occurred in patients who were initially considered to be steroid nonresponders or in relapse. Fourteen of the 49 episodes (28.6%) were asymptomatic. One child had Grade IV reflux and another had a ureteric calculus. The majority of the children had no underlying urinary tract malformations. The children with UTI had significantly lower serum albumin (P < 0.05) and higher serum cholesterol (P < 0.001) concentrations than the group of 206 children without infections. Non-Escherichia coli organisms accounted for 39% of the culture isolates.

CONCLUSIONS

We believe that UTI is an important but often underdiagnosed infection in children with nephrotic syndrome.

摘要

背景

旨在研究肾病综合征患儿尿路感染（UTI）的发生率、病因及易感因素。

方法

对所有肾病综合征患儿进行回顾性分析，以确定感染并发症的发生情况。

结果

UTI是最常见的感染（40.26%）；在37名儿童中观察到49次培养阳性的UTI发作。所有49次发作均发生在最初被认为对类固醇无反应或复发的患者中。49次发作中有14次（28.6%）无症状。一名儿童有IV级反流，另一名儿童有输尿管结石。大多数儿童没有潜在的尿路畸形。与206名未感染的儿童组相比，UTI患儿的血清白蛋白浓度显著降低（P < 0.05），血清胆固醇浓度显著升高（P < 0.001）。非大肠杆菌菌株占培养分离株的39%。