Wiener H, Van't Hof-Grootenboer A E, Vooijs G P
Department of Pathology, University of Nijmegen, The Netherlands.
Cytopathology. 1996 Aug;7(4):256-61. doi: 10.1046/j.1365-2303.1996.40682406.x.
The chromatin pattern of retrospectively Feulgen-Schiff-stained exfoliative urothelial cells was determined by computer-assisted analysis for 12 detailed texture image parameters. These were compared with density parameters and geometric parameters for their ability to discriminate between benign and malignant samples. The discriminatory power of the mean variable of the texture parameter sum variance was found to equal that of densitometric parameters which reflect the nuclear DNA content of the cell. The results suggest that determination of the texture parameter sum variance is valuable in distinguishing nuclei of specimens negative from those positive for malignancy.
通过计算机辅助分析，测定了12个详细纹理图像参数，以评估经福尔根-希夫染色的回顾性脱落尿路上皮细胞的染色质模式。将这些参数与密度参数和几何参数进行比较，以判断它们区分良性和恶性样本的能力。结果发现，纹理参数总和方差的平均变量的鉴别能力与反映细胞核DNA含量的密度参数相当。这些结果表明，测定纹理参数总和方差对于区分恶性阴性和阳性标本的细胞核具有重要价值。
