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Age-related changes in the global skeletal uptake of technetium-99m methylene diphosphonate in healthy women.

作者信息

Carnevale V, Frusciante V, Scillitani A, Modoni S, Pileri M, Chiodini I, Dicembrino F, Romagnoli E, Minisola S

机构信息

Ospedale "Casa Sollievo della Sofferenza", I.R.C.C.S. di San Giovanni Rotondo, Foggia, Italy.

出版信息

Eur J Nucl Med. 1996 Nov;23(11):1473-7. doi: 10.1007/BF01254471.

DOI:10.1007/BF01254471
PMID:8854845
Abstract

A short-term evaluation of global skeletal uptake (GSU) of technetium-99m methylene diphosphonate (MDP) was performed in 40 healthy female subjects with a wide age range in order to investigate the clinical performance of the technique and to detect the age-related changes in bone turnover. The results obtained were compared with measurements of the main biochemical markers of skeletal metabolism. We found that GSU increases progressively with age, independently of concomitant changes in renal function; significant correlations with biochemical markers of bone formation were also found. Therefore, the method appears to provide useful information concerning the bone turnover rate, and is also applicable to elderly people owing to its simplicity.

摘要

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本文引用的文献

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Bisphosphonates act on rat bone resorption through the mediation of osteoblasts.双膦酸盐通过成骨细胞的介导作用于大鼠的骨吸收。
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99Tcm-MDP global skeletal uptake and markers of bone metabolism in patients with bone diseases.99锝-亚甲基二膦酸盐在骨疾病患者中的全身骨骼摄取及骨代谢标志物
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Kinetics of 99mtechnetium-tin-methylene-diphosphonate in normal subjects and pathological conditions: a simple index of bone metabolism.99m锝-锡-亚甲基二膦酸盐在正常受试者和病理状态下的动力学：一种骨代谢的简易指标。
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Whole body retention of 99mTc-diphosphonate. Relation to biochemical indices of bone turnover and to total body calcium.99mTc-二膦酸盐的全身滞留。与骨转换生化指标及全身钙的关系。
Eur J Nucl Med. 1987;13(1):32-5. doi: 10.1007/BF00252643.
10
A new method for assessing 99Tcm-MDP bone uptake from a bone scan image: quantitative measurement of radioactivity in global skeletal regions of interest.一种从骨扫描图像评估99锝-亚甲基二膦酸盐（99Tcm-MDP）骨摄取的新方法：感兴趣的全身骨骼区域放射性的定量测量。
Nucl Med Commun. 1992 Jan;13(1):55-60. doi: 10.1097/00006231-199201000-00010.