Green C J, Allison A C, Precious S
Lancet. 1979 Jul 21;2(8134):123-5. doi: 10.1016/s0140-6736(79)90005-9.
A short period of daily treatment with cyclosporin A (25 mg/kg orally or 18 mg/kg by intramuscular injection) induced specific tolerance lasting more than 12 months in 60% of nephrectomised rabbits allografted with one kidney. Tolerant rabbits accepted second kidney and skin allografts from the original donor even though all immunosuppressive therapy had been withdrawn at least 70 days earlier, while third party allografts were rejected normally. These results strongly support the hypothesis that cyclosporin A induces operational tolerance to antigens in a donor-specific, not tissue-specific fashion.
对肾切除后移植了一个肾脏的兔每日短期给予环孢素A（口服25mg/kg或肌肉注射18mg/kg），可使60%的兔产生持续超过12个月的特异性耐受。耐受兔能接受来自原供体的第二个肾脏和皮肤移植，即使所有免疫抑制治疗至少在70天前就已停用，而对第三方移植则正常排斥。这些结果有力地支持了环孢素A以供体特异性而非组织特异性方式诱导对抗原的操作性耐受这一假说。
