Tiesler E, Hasler W
Immun Infekt. 1977 Jun;5(3):114-8.
Rabbits were immunized against staphylococcal nuclease by repeated intramuscular injections. After five weeks the peak of the antibody response was reached, after 17 weeks the titres are on the level of the starting point. Persons without staphylococcal infections showed titres between 1:200 and 1:300 (titre of normal). In patients with proved staphylococcal infection the peak of the titres is reached three month post infection. The level of the titre is influenced by the site of infection; deep infections gave higher values than superficial processes. The method of the AStaN-reaction was examined with respect of their reproducibility, clearness, specificity and diagnostic relevance. In proved staphylococcal infections the AStaN-reaction is more often positive than the AStaL-reaction.
通过反复肌肉注射，用葡萄球菌核酸酶对兔子进行免疫。五周后达到抗体反应峰值，十七周后滴度回到起始水平。无葡萄球菌感染的人滴度在1:200至1:300之间（正常滴度）。在已证实有葡萄球菌感染的患者中，感染后三个月达到滴度峰值。滴度水平受感染部位影响；深部感染的滴度值高于浅表感染。对AStaN反应的方法进行了再现性、清晰度、特异性和诊断相关性方面的检查。在已证实的葡萄球菌感染中，AStaN反应比AStaL反应更常呈阳性。
