大鼠脑中氯氮卓的含量
Brain levels of chloradiazepoyide in rats.
作者信息
Maleque A, Ahmad K
出版信息
Indian J Physiol Pharmacol. 1977 Apr-Jun;21(2):94-8.
PMID:885606
Abstract
The time-and dose-dependent uptake of chlordiazepoxide by the brain of rats was investigated and correlated with the blood levels of the drug. Peak concentration in the brain was reached in 10 min after i.p. injection of 25 mg/kg, and in 5 min with a dose of 50 mg/kg of the drug. Retention of chlordiazepoxide by the brain showed different characteristics dependeing on the size of the dose used.
摘要
研究了大鼠脑对氯氮卓的时间和剂量依赖性摄取，并将其与药物的血药浓度相关联。腹腔注射25mg/kg药物后10分钟达到脑内峰值浓度，注射50mg/kg药物时5分钟达到峰值浓度。脑对氯氮卓的保留表现出取决于所用剂量大小的不同特征。
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