Rodell T C
Cortech Inc., Denver, CO 80221, USA.
Immunopharmacology. 1996 Jun;33(1-3):279-83. doi: 10.1016/0162-3109(96)00071-9.
These data and others indicate that the kallikrein/kinin system is activated in both systemic and central nervous system trauma and that specific kinin antagonists are active in animal models of systemic and CNS trauma. In addition, preliminary data in humans suggest that kinin antagonists may have a role in the management of traumatic brain injury. Clearly, further studies in these indications are indicated.
这些数据及其他研究表明，激肽释放酶/激肽系统在全身和中枢神经系统创伤中均被激活，且特定的激肽拮抗剂在全身和中枢神经系统创伤的动物模型中具有活性。此外，人体的初步数据表明，激肽拮抗剂可能在创伤性脑损伤的治疗中发挥作用。显然，需要针对这些适应症开展进一步研究。
