Baxter M G, Bucci D J, Sobel T J, Williams M J, Gorman L K, Gallagher M
Department of Psychology, University of North Carolina, Chapel Hill 27599, USA.
Neuroreport. 1996 May 31;7(8):1417-20. doi: 10.1097/00001756-199605310-00019.
The role of the basal forebrain cholinergic system in learning and memory has held considerable interest since the discovery of cholinergic neurodegeneration in the basal forebrain in Alzheimer's disease. Contrary to expectation, selective removal of basal forebrain cholinergic neurons projecting to either hippocampus or neocortex fails to impair learning in a spatial task widely used to study hippocampal/cortical function. If cholinergic neurons contribute to learning and memory by integrated regulation of hippocampal and cortical processing, combined removal of hippocampal and cortical cholinergic projections might be necessary to produce impairment. However, this combined lesion failed to impair spatial learning. These data argue against the view that basal forebrain cholinergic deficiency plays a prominent role in disorders of learning and memory.
自阿尔茨海默病患者基底前脑出现胆碱能神经变性被发现以来，基底前脑胆碱能系统在学习和记忆中的作用一直备受关注。与预期相反，选择性去除投射至海马体或新皮层的基底前脑胆碱能神经元，并不会损害广泛用于研究海马体/皮层功能的空间任务中的学习能力。如果胆碱能神经元通过对海马体和皮层加工过程的综合调节来促进学习和记忆，那么可能需要同时去除海马体和皮层的胆碱能投射才会导致学习障碍。然而，这种联合损伤并未损害空间学习能力。这些数据反驳了基底前脑胆碱能缺乏在学习和记忆障碍中起主要作用的观点。
