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肠道M细胞的生命历程与时代

The life and times of an intestinal M cell.

作者信息

Savidge T C

机构信息

Dept of Cellular Physiology, Babraham Institute, Cambridge, UK.

出版信息

Trends Microbiol. 1996 Aug;4(8):301-6. doi: 10.1016/0966-842x(96)10052-4.

DOI:10.1016/0966-842x(96)10052-4
PMID:8856867
Abstract

Intestinal M cells are specialized epithelial antigen-sampling cells, strategically located over mucosal lymphoid follicles. They regulate the entry of antigen required for mucosal immune responses. There are several potential mechanisms involved in the induction of intestinal M cells. Both luminal antigen and B cells appear to have an influence on these altered epithelial differentiation pathways.

摘要

肠道M细胞是特殊的上皮抗原采样细胞,战略性地位于黏膜淋巴滤泡上方。它们调节黏膜免疫反应所需抗原的进入。肠道M细胞的诱导涉及多种潜在机制。管腔内抗原和B细胞似乎都对这些改变的上皮分化途径有影响。

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The life and times of an intestinal M cell.肠道M细胞的生命历程与时代
Trends Microbiol. 1996 Aug;4(8):301-6. doi: 10.1016/0966-842x(96)10052-4.
2
Molecular insights into the mechanisms of M-cell differentiation and transcytosis in the mucosa-associated lymphoid tissues.对黏膜相关淋巴组织中M细胞分化和转胞吞作用机制的分子见解。
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Migration of antigen-presenting B cells from peripheral to mucosal lymphoid tissues may induce intestinal antigen-specific IgA following parenteral immunization.抗原呈递B细胞从外周淋巴组织迁移至黏膜淋巴组织可能会在肠胃外免疫后诱导肠道抗原特异性IgA产生。
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The gut as a lymphoepithelial organ: the role of intestinal epithelial cells in mucosal immunity.作为淋巴上皮器官的肠道:肠上皮细胞在黏膜免疫中的作用。
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Lymphocyte compartments in antigen-sampling regions of rabbit mucosal lymphoid organs.兔黏膜淋巴器官抗原采样区域的淋巴细胞区室
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The regulation of mucosal immune system.黏膜免疫系统的调节
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A novel antigen is common to the dome epithelium of gut- and bronchus-associated lymphoid tissues.一种新型抗原在肠道和支气管相关淋巴组织的圆顶上皮中普遍存在。
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The membranous epithelial (M) cell and the mucosal immune system.膜性上皮(M)细胞与黏膜免疫系统。
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Collaboration of epithelial cells with organized mucosal lymphoid tissues.上皮细胞与有组织的黏膜淋巴组织的协作。
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Is there evidence that the gut contributes to mucosal immunity in humans?是否有证据表明肠道对人类的黏膜免疫有贡献?
JPEN J Parenter Enteral Nutr. 2007 May-Jun;31(3):246-58. doi: 10.1177/0148607107031003246.

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The B-cell system of human mucosae and exocrine glands.人类黏膜和外分泌腺的B细胞系统。
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The development of M cells in Peyer's patches is restricted to specialized dome-associated crypts.派尔集合淋巴结中M细胞的发育局限于特化的圆顶相关隐窝。
Am J Pathol. 1999 May;154(5):1573-82. doi: 10.1016/S0002-9440(10)65410-7.
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Human intestinal M cells display the sialyl Lewis A antigen.人类肠道M细胞表达唾液酸化路易斯A抗原。
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