Santoro M G
Institute of Experimental Medicine, CNR, Rome, Italy.
EXS. 1996;77:337-57. doi: 10.1007/978-3-0348-9088-5_23.
The relationship between viruses and the cellular stress response is a multifaceted and complex phenomenon which depends on the structural and genetic characteristics of the virus, on the type of infection, as well as on the environmental conditions. It is now well documented that infection of mammalian cells by several types of RNA and DNA viruses often results in alterations of the cellular stress response. Interactions between stress proteins and viral components have been described in a large variety of experimental models at different stages of the viral life cycle, depending on the type of virus and host cell. The presence of heat shock proteins in intact virions has also been described. On the other hand, induction of HSP expression by hyperthermia or other agents results in alterations of the virus replication cycle during acute or persistent infections of mammalian cells, and a possible role of heat shock proteins in the beneficial effect of fever and local hyperthermia during acute infection has been hypothesized. This chapter describes the different aspects of the interaction between viruses and the stress response, and discusses the possible role of stress proteins in the control of virus replication and morphogenesis.
病毒与细胞应激反应之间的关系是一个多方面且复杂的现象，它取决于病毒的结构和遗传特征、感染类型以及环境条件。现在有充分的文献记载，多种RNA和DNA病毒感染哺乳动物细胞通常会导致细胞应激反应的改变。在病毒生命周期的不同阶段，根据病毒和宿主细胞的类型，在大量实验模型中都描述了应激蛋白与病毒成分之间的相互作用。完整病毒粒子中热休克蛋白的存在也已被描述。另一方面，热疗或其他因素诱导热休克蛋白表达会导致在哺乳动物细胞急性或持续性感染期间病毒复制周期的改变，并且有人推测热休克蛋白在急性感染期间发热和局部热疗的有益作用中可能发挥作用。本章描述了病毒与应激反应相互作用的不同方面，并讨论了应激蛋白在控制病毒复制和形态发生中的可能作用。
