Soria A, Chicco A, Mocchiutti N, Gutman R A, Lombardo Y B, Martín-Hidalgo A, Herrera E
Department of Biochemistry, University of Litoral, Santa Fe, Argentina.
J Nutr. 1996 Oct;126(10):2481-6. doi: 10.1093/jn/126.10.2481.
A sucrose-rich diet (SRD) causes hypertriglyceridemia in nonpregnant rats. To determine whether a SRD further enhances gestational hypertriglyceridemia, female rats were divided into the following two groups: 1) rats fed a SRD (63 g sucrose/100 g), and 2) rats that received the same diet except that the sucrose was replaced by an equal amount of cornstarch (CD). Half of the rats were mated and studied at d 20 of gestation. Body weight increase did not differ between virgin rats fed either diet, but the final body weight of pregnant rats fed SRD was lower than that of rats fed CD due to fewer fetuses per litter and lower fetal and placental weights. The SRD enhanced plasma glucose and insulin concentrations in virgin but not in pregnant rats; plasma triglycerides and FFA concentrations and the rate of triglyceride secretion into the plasma were higher in pregnant than in virgin rats fed SRD, but the increase in liver triglycerides due to SRD was higher in virgin rats. Both removal rate of a fat emulsion and adipose tissue lipoprotein lipase activity (LPL) were lower in virgin rats fed SRD than in those fed CD. They were lower in pregnant than in virgin rats fed CD. Placental and fetal liver triglyceride concentration and placental LPL were higher in rats fed SRD than in those fed CD. Both the increased triglyceride secretion by the liver and the decreased triglyceride removal from blood resulting in maternal hypertriglyceridemia may contribute to the negative effect of SRD on the developing fetus.
富含蔗糖的饮食（SRD）会导致未怀孕大鼠出现高甘油三酯血症。为了确定SRD是否会进一步加重妊娠期高甘油三酯血症，将雌性大鼠分为以下两组：1）喂食SRD（63克蔗糖/100克）的大鼠，以及2）接受相同饮食但蔗糖被等量玉米淀粉替代的大鼠（CD）。一半的大鼠交配并在妊娠第20天进行研究。两种饮食喂养的未孕大鼠体重增加无差异，但由于每窝胎儿数量较少以及胎儿和胎盘重量较低，喂食SRD的怀孕大鼠的最终体重低于喂食CD的大鼠。SRD提高了未孕大鼠而非怀孕大鼠的血浆葡萄糖和胰岛素浓度；与喂食SRD的未孕大鼠相比，喂食SRD的怀孕大鼠的血浆甘油三酯和游离脂肪酸（FFA）浓度以及甘油三酯分泌到血浆中的速率更高，但SRD导致的未孕大鼠肝脏甘油三酯增加幅度更大。喂食SRD的未孕大鼠脂肪乳剂清除率和脂肪组织脂蛋白脂肪酶活性（LPL）均低于喂食CD的大鼠。喂食CD的怀孕大鼠的上述指标低于未孕大鼠。喂食SRD的大鼠胎盘和胎儿肝脏甘油三酯浓度以及胎盘LPL均高于喂食CD的大鼠。肝脏甘油三酯分泌增加和血液中甘油三酯清除减少导致母体高甘油三酯血症，这两者都可能是SRD对发育中胎儿产生负面影响的原因。
