奥氮平治疗帕金森病患者的多巴胺能精神病

Olanzapine in the treatment of dopaminomimetic psychosis in patients with Parkinson's disease.

作者信息

Wolters E C, Jansen E N, Tuynman-Qua H G, Bergmans P L

机构信息

Graduate School of Neurosciences Amstordam, The Netherlands.

出版信息

Neurology. 1996 Oct;47(4):1085-7. doi: 10.1212/wnl.47.4.1085.

DOI:10.1212/wnl.47.4.1085

PMID:8857751

Abstract

We studied the effect of olanzapine (1 to 15 mg/d) in 15 nondemented parkinsonian patients with drug-induced psychosis. Psychotic symptoms decreased significantly during treatment, and there was no worsening of extrapyramidal symptoms. These results suggest that olanzapine is a well-tolerated and effective treatment for drug-induced psychosis in nondemented patients with Parkinson's disease.

摘要

我们研究了奥氮平（1至15毫克/天）对15名非痴呆帕金森病患者药物性精神病的疗效。治疗期间精神病症状显著减轻，锥体外系症状未加重。这些结果表明，奥氮平是治疗非痴呆帕金森病患者药物性精神病耐受性良好且有效的药物。