半合成β-内酰胺抗生素。II. 源自α-肼基芳基乙酸的青霉素。
Semisynthetic beta-Lactam antibiotics. II. Penicillins from alpha-hydrazinoarylacetic acids.
作者信息
LiBassi G, Monguzzi R, Broggi R, Broccali G, Carpi C, Pifferi G
出版信息
J Antibiot (Tokyo). 1977 May;30(5):376-82. doi: 10.7164/antibiotics.30.376.
PMID:885795
Abstract
A number of penicillins (2) have been synthesized from the alpha-hydrazinoarylacetic acids (4) via the activated chloride hydrochlorides (5) or via the mixed anhydride of the corresponding N2-benzyloxycarbonyl derivatives (6). The penicillins, 2b, e, j, show good activity against gram-positive and gram-negative bacteria and enhanced penicillinase resistance in comparison with ampicillin.
摘要
已经通过活性氯化氢（5）或相应的N2 - 苄氧羰基衍生物的混合酸酐（6），由α-肼基芳基乙酸（4）合成了多种青霉素（2）。青霉素2b、2e、2j对革兰氏阳性菌和革兰氏阴性菌显示出良好的活性，并且与氨苄青霉素相比，对青霉素酶的抗性增强。
Zotero 插件