Raanani P, Berkowicz M, Rosner E, Rosenthal E, Berman S, Rechavi G, Ben-Bassat I
Institute of Haematology, Chaim Sheba Medical Centre, Tel-Hashomer, Israel.
Br J Haematol. 1996 Oct;95(1):131-4. doi: 10.1046/j.1365-2141.1996.d01-1882.x.
We report on two adult patients with CD10+ positive acute lymphoblastic leukaemia (ALL) who presented with similar clinical and laboratory features and with a new chromosomal translocation: t(3;17)(q23;q21). This translocation may be involved in the formation of a new chimaeric transcription factor. Both patients shared several poor prognostic factors at presentation and an adverse clinical course. The t(3;17)(q23;q21) translocation may therefore predict a poor outcome in ALL.
我们报告了两名患有CD10 +阳性急性淋巴细胞白血病（ALL）的成年患者，他们具有相似的临床和实验室特征，并伴有一种新的染色体易位：t(3;17)(q23;q21)。这种易位可能参与了一种新的嵌合转录因子的形成。两名患者在初诊时均具有几个不良预后因素，并经历了不良的临床病程。因此，t(3;17)(q23;q21)易位可能预示着ALL患者的预后不良。
