采用反相高效液相色谱法测定头孢拉定和头孢氨苄。

The determination of cephradine and cephalexin by reverse phase high-performance liquid chromatography.

作者信息

Carrol M A, White E R, Jancsik Z, Zarembo J E

出版信息

J Antibiot (Tokyo). 1977 May;30(5):397-403. doi: 10.7164/antibiotics.30.397.

DOI:10.7164/antibiotics.30.397

Abstract

The application of reverse phase high-performance liquid chromatography to the separation and analysis of cephradine and cephalexin is demonstrated. The procedure has been applied to chemicals, pharmaceutical formulations and reaction solutions. The preparation of samples is simple and rapid. Chromatographic conditions are described for both pellicular and small particle columns. The feasibility of determing cephradine and cephalexin in physiological fluids has also been demonstrated.

摘要

本文展示了反相高效液相色谱法在头孢拉定和头孢氨苄分离与分析中的应用。该方法已应用于化学药品、药物制剂及反应溶液。样品制备简单快速。文中描述了薄壳型柱和小颗粒柱的色谱条件。同时也证明了在生理体液中测定头孢拉定和头孢氨苄的可行性。