头孢拉定、头孢氨苄和头孢甘氨酸的荧光测定法。
Fluorimetric assay of cephradine, cephalexin and cephaloglycin.
作者信息
Barbhaiya R H, Turner P
出版信息
Br J Clin Pharmacol. 1977 Aug;4(4):427-31. doi: 10.1111/j.1365-2125.1977.tb00757.x.
Abstract
1 A simple, rapid and reproducible fluorimetric assay for cephradine, cephalexin and cephaloglycin is described. 2 The method involves addition of formaldehyde which catalyses the formation of fluorescent derivatives. 3 The structural similarities between the side chains of these antibiotics and their identical excitation and emission spectra suggest that they may be forming similar fluorescent derivatives.
摘要
- 本文描述了一种用于头孢拉定、头孢氨苄和头孢甘氨酸的简单、快速且可重复的荧光测定法。2. 该方法包括加入甲醛，甲醛可催化荧光衍生物的形成。3. 这些抗生素侧链之间的结构相似性以及它们相同的激发光谱和发射光谱表明，它们可能形成相似的荧光衍生物。
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Br J Clin Pharmacol. 1977 Aug;4(4):427-31. doi: 10.1111/j.1365-2125.1977.tb00757.x.
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本文引用的文献
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Pharmacokinetics of the cephalosporins in healthy volunteers and uremic patients.头孢菌素类药物在健康志愿者和尿毒症患者体内的药代动力学。
Postgrad Med J. 1971 Feb;47:Suppl:41-6.
2
Fluorometric analysis of ampicillin in biological fluids.生物体液中氨苄西林的荧光分析
J Pharm Sci. 1971 May;60(5):728-32. doi: 10.1002/jps.2600600514.
3
Colorimetric estimation of cephalexin, cephaloglycin, and related compounds.头孢氨苄、头孢甘氨酸及相关化合物的比色测定
J Pharm Sci. 1972 Oct;61(10):1647-8. doi: 10.1002/jps.2600611026.
4
Cephaloglycin and its biologically active metabolite desacetylcephaloglycin.头孢甘氨酸及其生物活性代谢物去乙酰头孢甘氨酸。
Appl Microbiol. 1971 Mar;21(3):426-34. doi: 10.1128/am.21.3.426-434.1971.
5
Problems in the bio-assay of orally administered cephaloglycin in biological fluids and method for the detection of its metabolite, desacetylcephaloglycin.生物流体中口服头孢甘氨酸生物测定的问题及其代谢物去乙酰头孢甘氨酸的检测方法。
J Antibiot (Tokyo). 1970 Apr;23(4):216-22. doi: 10.7164/antibiotics.23.216.
6
Cephradine: absorption, excretion, and tissue distribution in animals of a new cephalosporin antibiotic.头孢拉定：一种新型头孢菌素抗生素在动物体内的吸收、排泄及组织分布
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7
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