Clarnette T D, Hutson J M
F. Douglas Stephens Surgical Research Laboratory, Royal Children's Hospital, Parkville, Victoria, Australia.
Aust N Z J Surg. 1996 Sep;66(9):612-7. doi: 10.1111/j.1445-2197.1996.tb00831.x.
The genitofemoral nerve (GFN) hypothesis for inguinoscrotal testicular descent proposes that calcitonin gene-related peptide (CGRP), released from the genitofemoral nerve, controls the migration of the gubernaculum from the inguinal region to the scrotum between 26 and 40 weeks of gestation. The processus vaginalis provides a channel through which the testis descends from the abdomen to the scrotum. Following descent of the testis the processus vaginalis undergoes luminal obliteration and disappearance between the internal inguinal ring and the upper pole of the testis. The mechanism underlying closure of the processus is unknown and failure for it to occur normally results in congenital inguinal hernia, scrotal hydrocele and possibly even an 'ascending' testis. Recent work in our laboratory suggests that CGRP, released from the genitofemoral nerve, may cause fusion and disappearance of the processus vaginalis. We propose that abnormalities in the GFN link a spectrum of disorders encompassing congenital undescended testis, inguinal hernia, scrotal hydrocele and ascending testis.
关于腹股沟阴囊型睾丸下降的生殖股神经（GFN）假说提出，在妊娠26至40周期间，由生殖股神经释放的降钙素基因相关肽（CGRP）控制睾丸引带从腹股沟区向阴囊的迁移。鞘突提供了睾丸从腹部下降至阴囊的通道。睾丸下降后，鞘突在腹股沟内环与睾丸上极之间管腔闭塞并消失。鞘突闭合的潜在机制尚不清楚，其正常发生失败会导致先天性腹股沟疝、阴囊鞘膜积液，甚至可能导致“上升”睾丸。我们实验室最近的研究表明，由生殖股神经释放的CGRP可能导致鞘突融合和消失。我们提出，生殖股神经异常与一系列疾病相关，包括先天性隐睾、腹股沟疝、阴囊鞘膜积液和上升睾丸。
