UNC-40是结直肠癌缺失基因（DCC）在秀丽隐杆线虫中的同源物，在响应UNC-6网蛋白信号的运动细胞中是必需的。

UNC-40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues.

作者信息

Chan S S, Zheng H, Su M W, Wilk R, Killeen M T, Hedgecock E M, Culotti J G

机构信息

Samuel Lunenfeld Research Institute, Mt. Sinai Hospital, Toronto, Ontario, Canada.

出版信息

Cell. 1996 Oct 18;87(2):187-95. doi: 10.1016/s0092-8674(00)81337-9.

DOI:10.1016/s0092-8674(00)81337-9

PMID:8861903

Abstract

UNC-6 netrin, a laminin-related protein secreted from neuroglia and neurons along the ventral midline, orients migrating cells and pioneering growth cones on the nematode epidermis. UNC-5, a cell surface protein expressed on motile cells and pioneer axons, orients movements away from UNC-6 sources. UNC-40, a homolog of the cell surface proteins DCC (Deleted in Colorectal Cancer) and neogenin, is also expressed on motile cells and pioneer neurons. UNC-40 acts cell autonomously to orient movement toward UNC-6 sources. For cells coexpressing UNC-5, it helps orient movement away from UNC-6 sources. Finally, UNC-40 helps determine the dorsoventral position of cells undergoing purely longitudinal migrations. Together with the recent report that DCC is a netrin receptor in vertebrates, our results suggest that UNC-40 is a component of UNC-6 receptors on motile cells.

摘要

UNC-6网蛋白是一种与层粘连蛋白相关的蛋白质，由神经胶质细胞和沿腹中线的神经元分泌，它能引导迁移细胞和线虫表皮上的先驱生长锥。UNC-5是一种在运动细胞和先驱轴突上表达的细胞表面蛋白，它引导细胞向远离UNC-6来源的方向运动。UNC-40是细胞表面蛋白DCC（结直肠癌缺失基因）和新基因的同源物，也在运动细胞和先驱神经元上表达。UNC-40自主发挥作用，引导细胞向UNC-6来源的方向运动。对于共表达UNC-5的细胞，它有助于引导细胞向远离UNC-6来源的方向运动。最后，UNC-40有助于确定进行纯纵向迁移的细胞的背腹位置。结合最近关于DCC是脊椎动物中网蛋白受体的报道，我们的结果表明UNC-40是运动细胞上UNC-6受体的一个组成部分。