Manoukian A V, Carson J L
Division of Gastroenterology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, USA.
Drug Saf. 1996 Jul;15(1):64-71. doi: 10.2165/00002018-199615010-00005.
The nonsteroidal anti-inflammatory drugs (NSAIDs) are the most frequently used medications worldwide for the treatment of a variety of common chronic and acute inflammatory conditions. The association between NSAIDs and liver disease is poorly documented, the exceptions being sulindac and, to a lesser degree, diclofenac. The incidence of liver disease is very low and is relatively unimportant compared with the risk of peptic ulcer disease and gastrointestinal bleeding. Reports of hepatic injury range from insignificant and transient liver enzyme elevation to severe and fulminant hepatitis.
非甾体抗炎药（NSAIDs）是全球范围内治疗各种常见慢性和急性炎症性疾病最常用的药物。NSAIDs与肝脏疾病之间的关联记录较少，舒林酸是个例外，双氯芬酸在较小程度上也是如此。肝脏疾病的发病率非常低，与消化性溃疡疾病和胃肠道出血的风险相比相对不那么重要。肝损伤的报告范围从无明显症状的短暂肝酶升高到严重的暴发性肝炎。
