Yoshida S, Oshima K, Tanne K
Hiroshima University Dental Hospital, Japan.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996 Aug;82(2):152-60. doi: 10.1016/s1079-2104(96)80218-6.
This study was conducted to investigate biologic responses of the pulp to single-tooth dento-osseous osteotomy and to explore an appropriate level of transverse bone resection for maintaining biologic activity of the pulp in monkeys.
The levels of transverse bone resection were designed at approximately 10 mm (10 mm group) and 5 mm (5 mm group) above the apices. Histologic and histomorphometric changes were evaluated microscopically, and changes in blood flow in the pulp were also measured in terms of vascular responses to a vasoconstrictor (noradrenaline, NA).
Vacuolar degeneration in the pulp chamber associated with less number of the pulp cells were more prominent in the 5 mm group, and the response of blood flow to NA was maintained better in the 10-mm group.
It is shown in this 8-week experiment that biologic activity of the pulp is much better preserved in the 10-mm group than in the 5-mm group, whereas the pulpal response may become similar if observed for a longer period.
本研究旨在调查牙髓对单牙牙骨切开术的生物学反应，并探索维持猴牙髓生物学活性的合适横向骨切除水平。
横向骨切除水平设计为根尖上方约10毫米（10毫米组）和5毫米（5毫米组）。通过显微镜评估组织学和组织形态学变化，并根据牙髓对血管收缩剂（去甲肾上腺素，NA）的血管反应测量牙髓内的血流变化。
5毫米组牙髓腔内空泡变性更明显，牙髓细胞数量更少，而10毫米组对NA的血流反应维持得更好。
在这个为期8周的实验中表明，10毫米组牙髓的生物学活性比5毫米组保存得好得多，而如果观察更长时间，牙髓反应可能会变得相似。
