Krongrad A, Lai H, Burke M A, Goodkin K, Lai S
Department of Urology, University of Miami School of Medicine, Florida, USA.
J Urol. 1996 Nov;156(5):1696-70.
We evaluated the association of marital status and survival in patients with prostate cancer.
Using the 146,979 prostate cancer patients of the 1973 to 1990 public use tape of the Surveillance, Epidemiology and End Results program we performed survival analysis and multivariate proportional hazards modeling to estimate the relative risk of mortality.
Married patients had significantly longer median survival than those who were divorced, single, separated or widowed. In models that controlled for age, stage, race and treatment, married patients had a significantly lower risk of mortality than those who were divorced, single, separated or widowed.
Several hypothetical models can explain the association of marital status and mortality in men with prostate cancer. The most attractive model relies on the putative salutary effects of being married on social support and/or mood. A social support and depressed mood model of mortality raises the possibility that in prostate cancer quality of life determines quantity of life. Understanding the relationships among marital status, social support, mood and mortality could open the way to rational strategies for postponing death in men with prostate cancer.
我们评估了前列腺癌患者的婚姻状况与生存率之间的关联。
利用监测、流行病学和最终结果计划1973年至1990年公开使用磁带中的146,979例前列腺癌患者，我们进行了生存分析和多变量比例风险建模，以估计死亡的相对风险。
已婚患者的中位生存期明显长于离婚、单身、分居或丧偶患者。在控制了年龄、分期、种族和治疗的模型中，已婚患者的死亡风险明显低于离婚、单身、分居或丧偶患者。
有几种假设模型可以解释前列腺癌男性患者婚姻状况与死亡率之间的关联。最有吸引力的模型依赖于婚姻对社会支持和/或情绪的假定有益影响。一种社会支持和抑郁情绪导致死亡的模型提出了这样一种可能性，即在前列腺癌中，生活质量决定生命数量。了解婚姻状况、社会支持、情绪和死亡率之间的关系可能为延缓前列腺癌男性患者死亡的合理策略开辟道路。
