Ghadially F N, Lowes N R, Mesfin G M
J Pathol. 1977 Jul;122(3):157-62. doi: 10.1002/path.1711220307.
A solitary, benign plasmacytoma, arising from the gum of the lower jaw of a dog, was studied by light and electron microscopy. Some of the tumour cell nuclei showed the characteristic clockface or cartwheel pattern of heterochromatin distribution similar to that found in normal plasma cells. Like normal plasma cells the tumour cells were endowed with rough endoplasmic reticulum but this was invariably dilated or visiculated. Glycogen deposits were found within mitochondria and within the dilated and vesiculated rough endoplasmic reticulum. The idea that these deposits were derived secondarily from glycogen deposits in the cytoplasm seems untenable because no glycogen particles were found in the cytoplasmic matrix. It would therefore appear that most, perhaps all, stages of glycogen synthesis occurred within the mitochondria and rough endoplasmic reticulum of some of these tumour cells.
对一只狗下颌牙龈处发生的孤立性良性浆细胞瘤进行了光镜和电镜研究。部分肿瘤细胞核显示出异染色质分布的特征性钟面或车轮状模式，类似于正常浆细胞中的情况。与正常浆细胞一样，肿瘤细胞含有粗面内质网，但总是扩张或形成泡状。在线粒体以及扩张和泡状的粗面内质网内发现了糖原沉积。这些沉积物继发于细胞质中的糖原沉积这一观点似乎站不住脚，因为在细胞质基质中未发现糖原颗粒。因此，看来这些肿瘤细胞中的一些细胞的糖原合成的大部分阶段，也许是所有阶段，都发生在线粒体和粗面内质网内。
