Chachich M, Penney J, Powell D A
Neuroscience Laboratory, William Jennings Bryan Dorn Veterans Affairs Medical Center, Columbia, South Carolina 29201, USA.
Behav Neurosci. 1996 Aug;110(4):707-17. doi: 10.1037//0735-7044.110.4.707.
Rabbits and rats received horseradish peroxidase injections in the medial prefrontal cortex, and retrograde labeling was examined in the hippocampus (HC) and subicular complex (SC). Labeled cells were observed in HC and SC in the rat, but only in the SC of the rabbit. In a second experiment, separate groups of rabbits with sham, SC, or cortical control lesions were subjected to differential classical heart rate conditioning, in which 4-s, 75-db tones served as conditioned stimuli and a 3-mA paraorbital shock was the unconditioned stimulus. Although conditioned bradycardia was obtained in animals with SC lesions, it was slower to develop and was much shorter in duration than in the cortical and sham control groups. In the animals with SC lesions, the bradycardiac response was quickly replaced with tachycardia, suggesting a sympathetic bias in these animals.
给兔子和大鼠在内侧前额叶皮层注射辣根过氧化物酶，并检查海马体（HC）和海马旁复合体（SC）中的逆行标记。在大鼠的海马体和海马旁复合体中观察到标记细胞，但在兔子中仅在海马旁复合体中观察到。在第二项实验中，将分别有假手术、海马旁复合体或皮层对照损伤的几组兔子进行差异经典心率条件反射，其中4秒、75分贝的音调作为条件刺激，3毫安眶旁电击作为非条件刺激。尽管在有海马旁复合体损伤的动物中获得了条件性心动过缓，但它的发展较慢，持续时间比皮层和假手术对照组短得多。在有海马旁复合体损伤的动物中，心动过缓反应很快被心动过速取代，表明这些动物存在交感神经偏向。
