Schafe G E, Stein P L, Park C R, Bernstein I L
Department of Psychology, University of Washington, Seattle 98195-1525, USA.
Behav Neurosci. 1996 Aug;110(4):845-8.
Conditioned taste aversion (CTA) learning is a robust form of classical conditioning in which animals rapidly associate a flavor with aversive internal symptoms. The present study assessed CTA learning in transgenic mice deficient in a specific nonreceptor tyrosine kinase (the fyn mutant). Fyn mutants show impaired long-term potentiation and marked deficits in acquisition of spatial learning tasks. To assess whether they are also impaired in CTA learning, fyn mutant and wild-type mice received 2 conditioning trials consisting of access to a flavored solution followed by administration of LiCl. Fyn mutant mice acquired significant CTAs following a single conditioning trial and these aversions were comparable to those seen in wild-type mice. These results indicate that the fyn mutation does not interfere with the acquisition of CTAs and hence that this mutation is not associated with a global learning deficit.
条件性味觉厌恶（CTA）学习是经典条件作用的一种强大形式，在此过程中动物会迅速将一种味道与厌恶的内部症状联系起来。本研究评估了缺乏特定非受体酪氨酸激酶的转基因小鼠（fyn突变体）的CTA学习情况。Fyn突变体表现出长时程增强受损以及在空间学习任务获取方面存在明显缺陷。为了评估它们在CTA学习中是否也受损，fyn突变体小鼠和野生型小鼠接受了2次条件性试验，包括给予一种有味溶液，随后注射氯化锂。fyn突变体小鼠在单次条件性试验后获得了显著的CTA，并且这些厌恶反应与野生型小鼠所见的相当。这些结果表明，fyn突变不会干扰CTA的获得，因此该突变与整体学习缺陷无关。
