de Argila D, Dominguez J D, Iglesias L
Department of Dermatology, Hospital Universitario Doce de Octubre, Madrid, Spain.
Dermatology. 1996;192(4):377-8. doi: 10.1159/000246419.
Chemotherapy-induced acral erythema is a peculiar localized cutaneous response to several chemotherapeutic agents, mostly antimetabolites. Taxol is a recently developed antineoplastic drug that acts on the mitotic spindle and does not interfere with nucleic acid synthesis. We describe the first case of taxol-induced acral erythema and report on additional data concerning the pathogenesis of this kind of toxic eruptions.