内皮素B（ETB）受体激活对人支气管中胆碱能神经介导收缩的增强作用。
EndothelinB (ETB) receptor-activated potentiation of cholinergic nerve-mediated contraction in human bronchus.
作者信息
Fernandes L B, Henry P J, Rigby P J, Goldie R G
机构信息
Department of Pharmacology, University of Western Australia, Nedlands, Australia.
出版信息
Br J Pharmacol. 1996 Aug;118(8):1873-4. doi: 10.1111/j.1476-5381.1996.tb15617.x.
Abstract
In human isolated bronchial preparations, the endothelinB (ETB) receptor-selective agonist, sarafotoxin S6c (Stx6c; 1 nM) increased nerve-mediated contraction in response to electrical field stimulation (EFS) at 0.5-1 Hz from 19 +/- 4% to 42 +/- 7% (n = 9). This effect was blocked in the presence of the ETB receptor-selective antagonist, BQ-788 (10 microM). These data are consistent with findings in some animal species that ET-1 and related peptides have marked neuromodulatory influences on the cholinergic system. Furthermore, they provide additional support for the concept that ET-1 may have a mediator role in bronchial obstruction in asthma.
摘要
在人离体支气管标本中，内皮素B（ETB）受体选择性激动剂，铃蟾毒素S6c（Stx6c；1 nM）可使电场刺激（EFS）频率为0.5 - 1 Hz时神经介导的收缩反应从19±4%增加至42±7%（n = 9）。在ETB受体选择性拮抗剂BQ - 788（10 μM）存在的情况下，该效应被阻断。这些数据与在一些动物物种中的发现一致，即内皮素 - 1（ET - 1）及相关肽对胆碱能系统具有显著的神经调节作用。此外，它们为ET - 1可能在哮喘支气管阻塞中起介质作用这一概念提供了更多支持。
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