Hsia D C, Kim C K, Kildsig D O
J Pharm Sci. 1977 Jul;66(7):961-7. doi: 10.1002/jps.2600660715.
The dissolution of a solid immersed in a solvent was considered as a consecutive process, consisting of a primary surface interaction leading to the production of a new surface at the solid-liquid interface, solvation of the solid at the interface, and transfer of the solvated solid into the bulk of the solution. The energy changes involved in each step were studied for the dissolution of m-tolylacetamide in hexane and heptane. An energy diagram was constructed according to the proposed dissolution mechanism. The heats of dissolution determined from the energy diagram agreed well with those obtained experimentally.
将固体浸入溶剂中的溶解过程被视为一个连续过程，它包括导致在固液界面产生新表面的初级表面相互作用、界面处固体的溶剂化以及溶剂化固体向溶液主体的转移。研究了间甲苯基乙酰胺在己烷和庚烷中溶解时每个步骤所涉及的能量变化。根据提出的溶解机理构建了能量图。从能量图确定的溶解热与实验获得的结果吻合良好。
