McKenna M J, DiStefano V
J Pharmacol Exp Ther. 1977 Aug;202(2):245-52.
The pharmacokinetics of inhaled carbon disulfide (CS2) vapor was evaluated in rats. Estimates of free CS2 and its nonvolatile, acid-labile metabolites (AL CS2) were made in a variety of rat tissues after an 8-hour inhalation exposure to CS2 vapor (2 mg/l of air). At the end of the exposure, all tissues examined contained appreciable amounts of the native solvent and AL CS2. Elimination of CS2 from the rat during the postexposure period was rapid and occurred primarily via the lungs. Excretion of AL CL2 occurred primarily via the kidneys and was prolonged with respect to that of free CS2. Accumulation of these metabolites upon repeated exposures and their presence in all tissues examined suggest that they may play a role in the toxicity of CS2.
在大鼠中评估了吸入二硫化碳（CS2）蒸气的药代动力学。在大鼠吸入CS2蒸气（2毫克/升空气）8小时后，对多种大鼠组织中的游离CS2及其非挥发性、酸不稳定代谢物（AL CS2）进行了估算。暴露结束时，所有检测的组织都含有相当数量的天然溶剂和AL CS2。在暴露后的时期，CS2从大鼠体内的消除很快，主要通过肺部进行。AL CL2的排泄主要通过肾脏，并且相对于游离CS2的排泄有所延长。这些代谢物在重复暴露时的积累以及它们在所检测的所有组织中的存在表明，它们可能在CS2的毒性中起作用。
