Végh A, Papp J G
Department of Pharmacology, Albert Szent-Györgyi Medical University, Budapest, Hungary.
Diabetes Res Clin Pract. 1996 Jul;31 Suppl:S43-53. doi: 10.1016/0168-8227(96)01229-6.
Antidiabetic sulphonylureas have attracted a great deal of interest in experimental cardiology to evaluate the role of ATP-sensitive potassium channels in the cardiovascular system. It is well established that KATP channels are present in cardiac cells and also in vascular smooth muscle cells and are implicated in the regulation of myocardial and vascular function. It follows that drugs which open, or inhibit the opening of these channels, might profoundly modify cardiovascular function both under physiological and pathophysiological conditions. This paper reviews the evidence for the role of KATP channels in the cardiovascular system and discusses how the different generations of sulphonylurea drugs interfere with cardiac function. We will particularly concentrate on the haemodynamic effects of different sulphonylureas and shortly discuss how these drugs modify ischaemia-reperfusion arrhythmias.
抗糖尿病磺脲类药物在实验心脏病学领域引起了广泛关注，用于评估ATP敏感性钾通道在心血管系统中的作用。众所周知，KATP通道存在于心肌细胞以及血管平滑肌细胞中，并参与心肌和血管功能的调节。因此，能够开放或抑制这些通道开放的药物，可能会在生理和病理生理条件下深刻改变心血管功能。本文综述了KATP通道在心血管系统中作用的证据，并讨论了不同代磺脲类药物如何干扰心脏功能。我们将特别关注不同磺脲类药物的血流动力学效应，并简要讨论这些药物如何改变缺血再灌注心律失常。
