Murer H, Biber J
Institute of Physiology, University of Zürich, Switzerland.
Exp Nephrol. 1996 Jul-Aug;4(4):201-4.
Two renal proximal tubular apical sodium-dependent transport systems for phosphate (Na/Pi cotransporter) have been identified. Recent studies demonstrated that the abundance of the type II Na/Pi cotransporter in the brush border is critical for the capacity of phosphate reabsorption. Evidence was obtained that a change of apical Na/Pi cotransporters may occur via endo/ exocytic processes and via protein-synthesis-dependent mechanisms involving altered transcription and/or stability of mRNA. In addition, acute control of apical Na/Pi cotransport may occur via the pH dependence and electrogenicity of the Na/Pi cotransporter.
已确定两种用于磷酸盐的肾近端小管顶端钠依赖性转运系统（钠/磷酸盐共转运体）。最近的研究表明，刷状缘中II型钠/磷酸盐共转运体的丰度对于磷酸盐重吸收能力至关重要。有证据表明，顶端钠/磷酸盐共转运体的变化变化/出胞过程以及涉及mRNA转录改变和/或稳定性的蛋白质合成依赖性机制可能会发生变化。此外，顶端钠/磷酸盐共转运的急性控制可能通过钠/磷酸盐共转运体的pH依赖性和电生性来实现。
