Robinson J W, Mirkovitch V, Sepúlveda F V, Menge H
J Physiol (Paris). 1977 Jun;73(1):5-12.
A characteristic secretory response in the dog jejunumis observed following three hours' perfusion with cholera toxin. When this mucosa in the secretory phase is examined in vitro, the steady-state accumulation of phenylalanine and beta-methyl-glucoside is considerably enhanced. Since the initial rates of influx of these substrates are unchanged and the tissue ion contents are the same as normal, it is concluded that the increase in steady-state uptake may be attributed to a change in the rate of efflux of the substrates across the baso-lateral membrane of the cell. This change might be related to the reported collapse of the intercellular channels when the intestine is in a secretory state.
用霍乱毒素灌注犬空肠三小时后，可观察到一种特征性的分泌反应。当在体外检查处于分泌期的这种黏膜时，苯丙氨酸和β-甲基葡萄糖苷的稳态积累显著增强。由于这些底物的初始流入速率未变且组织离子含量与正常时相同，因此得出结论，稳态摄取的增加可能归因于底物跨细胞基底外侧膜流出速率的变化。这种变化可能与报道的肠道处于分泌状态时细胞间通道的塌陷有关。
